The 3Rs working group . example, animals are invariably exposed to much higher doses than typical human exposures making interpretation difficult. The national centre for the replacement, refinement, and reduction of animals in research (NC3Rs) has issued ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are intended to improve the reporting of research using animals. 3Rs alternatives refer to the reduction, refinement, and replacement of animal use in research, testing, and teaching. Through improved research or production strategies, aimed at better quality, consistency and safety, reduction in the number of animals used can be substantial. The welfare of animals used in research is very important. NC3Rs (National Centre for the Replacement, Refinement and Reduction of Animals in Research) supports the implementation of these principles and provides more detailed information about what each involves.As well as providing a training video for scientists, technicians, students and others involved in animal research.. Animals used on Sanofi sites globally is 302 890 animals, more than 99% being rodents and fish. The 3Rs principles were first published in 1959 and have been embedded into UK and international legislature governing the use of animals in research and their humane treatment. The use of animals for research purposes including drug testing and experiments has long been a controversial subject that has raised concerns about the welfare of animals, the significant harm that might be inflicted on them and whether the justification for such harm is acceptable. The Babraham Institute is committed to the principles of the ‘3Rs’: Reduction, Refinement and Replacement for animals used during research. A number of international science ... Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), an organisation with a strong record in promoting the 3Rs in animal research. The 3Rs and Animal Welfare. NC3Rs. In 2013, NC3Rs awarded over £8.2 million to 3Rs projects investigating ways to reduce the numbers of animals used in research, or to improve the welfare of those currently used. an example of reduction in animal research is: speciesism. which animal group is used least often in laboratory research? human intolerance and discrimination of animals is known as: cats and dogs. requires accreditation of animal research facilities. There are good ethical, scientific, legal and economic reasons for making sure that animals are looked after properly and used in minimum numbers. In 2020, Sanofi has maintained its effort to replace and reduce the use of animals. Their mission is to use the principles of replacement, refinement and reduction to support scientific discovery, and address societal concerns about animal research. 4 Incorporate reduction, replacement, and refinement (the 3Rs) into your research, teaching, and ... confidence in the general public that animal research is being performed in an ethical manner. Refinement not only benefits animals, but can also improve the quality of research findings by reducing the level of stress in animals. For example, anaesthetics are used for surgery, and painkillers are given as necessary afterwards. The concept was developed by Russell and Burch in a 1959 book entitled Principles of Humane Experimental Technique (link is external). Since 2013, the overall reduction is 45%. By law, any distress or suffering to an animal must be kept to a minimum.

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